Key result
Rate-responsive biventricular pacing significantly increased the 6-minute walk distance by a mean of 18.8 m compared to fixed-rate pacing in patients with refractory AF and reduced LVEF (P<0.001).
Why the study?
Does rate-responsive biventricular pacing improve exercise capacity in patients with permanent AF, reduced LVEF, and AVJ ablation?
Population
60 patients with permanent, refractory atrial fibrillation and reduced LVEF treated with atrioventricular…
Comparison
Rate-responsive biventricular pacing vs Fixed-rate biventricular pacing (VVI 70/min)
Design
RCT, Randomly assigned to Group A or B, Single-blind
Follow-up
1 week apart
Authors
Loading...
Rate-responsive biventricular pacing warrants consideration after AVJ ablation; extends randomized CRT optimization data in permanent AF with reduced LVEF.
RCT (n=60)
Single-blind
Randomized crossover
Yes
Does rate-responsive biventricular pacing improve exercise capacity in patients with permanent AF, reduced LVEF, and AVJ ablation?
Mean Difference: 18.8
p-value: p=<0.001
In patients with permanent AF and reduced LVEF treated with AVJ ablation and biventricular pacing, rate-responsive pacing significantly improves exercise capacity compared to fixed-rate pacing.
Palmisano et al. (2016) conducted an RCT in Refractory atrial fibrillation and reduced LVEF (n=60). Rate-responsive biventricular pacing vs. Fixed-rate biventricular pacing (VVI 70/min) was evaluated on Distance walked during the 6-minute walking test (6MWT) (Mean increase of 18.8 m, p=<0.001). Rate-responsive biventricular pacing significantly increased the 6-minute walk distance by a mean of 18.8 m compared to fixed-rate pacing in patients with refractory AF and reduced LVEF (P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: