Key result
Serum ferritin level was an independent predictor of in-hospital mortality in hospitalized COVID-19 patients (OR 0.36; 95% CI 0.21-0.62; p<0.001).
Why the study?
This study aimed to investigate in-hospital mortality in severe acute respiratory syndrome coronavirus 2 patients stratified by serum ferritin levels.
Do higher serum ferritin levels (>1000) predict in-hospital mortality in hospitalized COVID-19 patients?
Observational
Do higher serum ferritin levels (>1000) predict in-hospital mortality in hospitalized COVID-19 patients?
Odds Ratio: 0.36 (95% CI 0.21–0.62)
p-value: p=<0.001
Higher levels of serum ferritin (>1000) serve as an independent predictor of in-hospital mortality in patients with COVID-19.
May support ferritin-based risk stratification in COVID-19; hypothesis-generating and should not yet change practice.
INTRODUCTION: This study aims to investigate in-hоsрitаl mоrtаlity in severe асute resрirаtоry syndrоme соrоnаvirus 2 раtients strаtified by serum ferritin levels. METHODS: Patients were stratified based on ferritin levels (ferritin levels ≤ 1000 or >1000). RESULTS: Approximately 89% (118) of the patients with ferritin levels > 1000 had pneumonia, and 51% (67) had hypertension. Fever (97, 73.5%) and shortness of breath (80, 61%) were two major symptoms among the patients in this group. Logistic regression analysis indicated that ferritin level (odds ratio [OR] = 0.36, 95% confidence interval [CI] = 0.21-0.62; p < .001), male sex (OR = 2.63, 95% CI = 1.43-5.06; p = .003), hypertension (OR = 4.16, 95% CI = 2.42-7.36; p < .001) and pneumonia (OR = 8.48, 95% CI = 3.02-35.45; p < .001) had significance in predicting in-hospital mortality. Additionally, the Cox proportional hazards analysis and Kaplan-Meier survival probability plot showed a higher mortality rate among patients with ferritin levels > 1000. CONCLUSION: In this study, higher levels of serum ferritin were found to be an independent predictor of in-hоsрitаl mоrtаlity.
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Alroomi et al. (2021) conducted an observational in COVID-19. Serum ferritin level vs. Lower serum ferritin levels was evaluated on In-hospital mortality (OR 0.36, 95% CI 0.21-0.62, p=<0.001). Serum ferritin level was an independent predictor of in-hospital mortality in hospitalized COVID-19 patients (OR 0.36; 95% CI 0.21-0.62; p<0.001).
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