Key result
Female rats showed a smaller increase in muscle beta-glucuronidase activity and less marked histopathological changes than male rats after eccentrically biased downhill running.
Population
Male and female rats
Comparison
Eccentrically biased downhill running exercise… vs Comparison between male and female rats
Design
Preclinical
Follow-up
4 days
Authors
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Indicates lower eccentric muscle damage in females; leaves open translation to human exercise responses.
Female rats exhibit less skeletal muscle fiber damage and slower histopathological changes than male rats following eccentrically biased downhill running.
KOMULAINEN et al. (1999) studied Skeletal muscle fibre damage. Eccentrically biased downhill running exercise vs. Male vs Female rats was evaluated on Muscle beta-glucuronidase activity and histopathological changes. Female rats showed a smaller increase in muscle beta-glucuronidase activity and less marked histopathological changes than male rats after eccentrically biased downhill running.
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