January 1, 1999Thrombosis and Haemostasis
The Utility of Animal Models in the Preclinical Study of Interventions to Prevent Human Coronary Artery Restenosis: Analysis and Recommendations
Key result
Animal models used in preclinical restenosis research show that large animals, particularly pigs, are more predictive of human success than small animals, though both have significant limitations.
Population
Small and large animal models used in preclinical coronary artery restenosis research
Design
Review
Authors
Discussion
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Member takes
Implication
Urges caution extrapolating small-animal restenosis data to patients; leaves open refinement of more predictive preclinical models.
Structured PICO
P
Population
Small and large animal models (including pigs and transgenic atherosclerotic animals) used in preclinical coronary artery restenosis research
I
Intervention
Interventions to prevent human coronary artery restenosis
O
Outcome
Predictive efficacy of animal models for human clinical success
Large animal models, particularly pigs, offer better predictive value for human coronary restenosis interventions than small animal models, highlighting the need for improved preclinical models.
Limitations
- Small animal models fail to closely simulate human atherosclerosis and stenotic lesions.
- The pig model has limitations that need to be overcome.
Cite This Study
Griggs et al. (1999) conducted a review in Coronary artery restenosis. Animal models was evaluated. Animal models used in preclinical restenosis research show that large animals, particularly pigs, are more predictive of human success than small animals, though both have significant limitations.