Effect of controlled adventitial heparin delivery on smooth muscle cell proliferation following endothelial injury.
Why the study?
Does controlled adventitial delivery of heparin reduce smooth muscle cell proliferation following endothelial injury in rats?
Population
Rats undergoing balloon deendothelialization of carotid arteries
Comparison
Ethylene-vinyl acetate copolymer matrices… vs Controls, intravenous pumps, or heparin/polymer…
Design
Preclinical
Follow-up
14 days
Authors
Discussion
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Implication
Adventitial heparin delivery may limit post-injury SMC proliferation without systemic effects in rats; leaves open translation to human restenosis prevention.
Structured PICO
Does controlled adventitial delivery of heparin reduce smooth muscle cell proliferation following endothelial injury in rats?
P
Population
Rats undergoing balloon deendothelialization of carotid arteries
I
Intervention
Ethylene-vinyl acetate copolymer matrices containing standard and modified heparin placed adjacent to rat carotid arteries
C
Comparator
Controls, intravenous pumps, or heparin/polymer matrices placed in a subcutaneous site distant from the injured carotid artery
O
Outcome
Arterial occlusion by smooth muscle cell proliferation at 14 dayssurrogate
Site-specific adventitial delivery of heparin effectively inhibits smooth muscle cell proliferation after vascular injury in rats without systemic side effects, suggesting a potential strategy to prevent restenosis after angioplasty.
Cite This Study
Edelman et al. (1990) studied this question.