Key result
Following oral lipid loading in patients with elevated fasting triglycerides, the area under the plasma triglyceride curve was significantly larger in the CAD group than controls (334 vs 233 mg/dl, p=0.02).
Why the study?
Is there a relationship between postprandial triglyceride levels following oral lipid loading and coronary artery disease?
Cohort (n=80)
Is there a relationship between postprandial triglyceride levels following oral lipid loading and coronary artery disease?
Absolute Event Rate: 334% vs 233%
p-value: p=0.02
Postprandial hypertriglyceridemia following a high-fat meal is associated with coronary artery disease specifically in patients who already have elevated fasting triglyceride levels.
Postprandial triglyceride response may mark CAD risk in hypertriglyceridemic patients; hypothesis-generating, requires prospective validation.
OBJECTIVE: We aimed to evaluate the relationship between postprandial triglyceride (PPTG) levels and coronary artery disease (CAD). METHODS: A total of 80 patients were included in this prospective cohort study. Oral lipid loading was used in order to measure PPTG levels. In the fasting state and after the high fat breakfast, triglyceride levels were measured by enzymatic methods at 2nd, 4th, 6th and 8th hours. We made subgroup analysis to show the effects of lipid loading on triglyceride levels in patients with and without fasting hypertriglyceridemia. We evaluated triglyceride levels and changes of triglyceride levels in percentages after lipid loading using a general linear model for repeated measures. Sample size analysis was performed. RESULTS: Baseline clinical, demographic and laboratory characteristics of both groups were similar. The peak triglyceride levels were seen at the 4th hour in both groups. Triglyceride levels were significantly increased after lipid-rich-breakfast loading compared to baseline levels in both groups (p<0.001) but these changes were not significant (p=0.279). In patients with elevated fasting triglyceride levels, the area under the plasma triglyceride concentration curve was significantly larger in CAD group than control group (334±103 vs. 233±58 mg/dl, p=0.02). CONCLUSION: Our data show that in patients who have a high fasting triglyceride level, high levels of PPTG may be related to CAD, however high PPTG levels are not related to CAD in patients with normal fasting levels of triglyceride.
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Atar et al. (2011) conducted a cohort in Coronary artery disease (n=80). Oral lipid loading vs. Control group was evaluated on Area under the plasma triglyceride concentration curve in patients with elevated fasting triglyceride levels (p=0.02). Following oral lipid loading in patients with elevated fasting triglycerides, the area under the plasma triglyceride curve was significantly larger in the CAD group than controls (334 vs 233 mg/dl, p=0.02).
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