Key result
Testosterone undecanoate increases LF/HF ratio vs placebo during low- and high-stress simulated military operations.
Why the study?
It was unknown whether exercise HRV serves as a marker of physical and psychological stress and whether testosterone administration maintains HRV during extended simulated military operations.
Does a single injection of testosterone undecanoate affect exercise heart rate variability in physically active males during simulated military operations?
Population
Thirty-two physically active males
Comparison
Single injection of testosterone undecanoate vs isovolumetric placebo
Design
Parallel arm, randomized, placebo-controlled, double-blind study
Follow-up
20 d
Authors
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Does not negatively affect autonomic response to stress; extends RCT evidence on testosterone in simulated military operations.
RCT (n=32)
Double-blind
Parallel arm
Does a single injection of testosterone undecanoate affect exercise heart rate variability in physically active males during simulated military operations?
p-value: P=0.006 (LS days), P<0.001 (HS days)
A single dose of testosterone undecanoate does not negatively affect the autonomic response to high stress in young, physically active males during simulated military operations.
Lowe et al. (2025) conducted an RCT in Physiological and psychological stress (n=32). Testosterone undecanoate vs. Isovolumetric placebo was evaluated on Exercise heart rate variability (SDNN, RMSSD, LF, HF, LF/HF ratio) (p=P=0.006 (LS days), P<0.001 (HS days)). A single injection of testosterone undecanoate resulted in a higher LF/HF ratio on low-stress (P=0.006) and high-stress (P<0.001) days compared with placebo during simulated military operations.
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