Key result
Armband PPG tracks AF burden with near-perfect ~0.98 correlation compared to ambulatory ECG.
Why the study?
Detecting AF is challenging due to its asymptomatic and paroxysmal nature, prompting the evaluation of automated photoplethysmography to detect AF, AF burden, and rhythm changes.
Does an automated three-channel photoplethysmography armband accurately detect atrial fibrillation rhythms and estimate AF burden compared to a standard ambulatory ECG in patients with recent-onset AF?
Observational (n=90)
No
Does an automated three-channel photoplethysmography armband accurately detect atrial fibrillation rhythms and estimate AF burden compared to a standard ambulatory ECG in patients with recent-onset AF?
A novel upper-arm three-channel photoplethysmography device provides highly accurate detection of atrial fibrillation and precise quantification of AF burden, presenting a promising tool for non-invasive arrhythmia screening.
May facilitate remote AF burden monitoring; extends PPG validation but remains hypothesis-generating pending broader outcome trials.
Aims: Atrial fibrillation (AF) is the most common arrhythmia, increasing stroke risk. Detecting AF is challenging due to its asymptomatic and paroxysmal nature. This study combines photoplethysmography (PPG) with automated techniques to detect AF, assess AF burden, and monitor rhythm changes from AF to sinus rhythm (SR). Methods and results: Ninety patients with recent-onset (duration <48 h) AF, scheduled for cardioversion, were monitored using a three-channel PPG armband on the upper arm. An ambulatory three-lead electrocardiogram (ECG) served as the gold standard. PPG recordings were segmented into 10-, 20-, 30-, and 60-min detection windows. Automated detection identified SR and AF episodes, rhythm changes, and AF burden. Sensitivities, specificities, positive predictive values (PPVs), and negative predictive values (NPVs) for rhythm detection were calculated, and the intraclass correlation coefficients (ICCs) for PPG-based AF burden were compared to the gold standard. Monitoring time ranged from 1.0 to 8.2 h per patient. Sensitivities, specificities, PPVs, and NPVs for AF detection were 93.9-94.6, 99.5-99.8, 99.4-99.7, and 93.7-95.0%, respectively. The ICC (0.97-0.98) indicated excellent agreement between PPG and the gold standard in estimating AF burden, with differences of -6.3 to -8.3 min (5.5-6.8%). Rhythm changes from AF to SR were detected in all patients (sensitivity 100%), with detection delays of 4.1 ± 1.4, 8.7 ± 2.8, 13.7 ± 3.9, and 27.8 ± 7.1 min depending on the detection window. Conclusion: Photoplethysmography with automated analysis shows promise in detecting AF, AF burden, and rhythm changes, indicating its potential in AF screening. Clinical trial registration: NCT04917653.
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Rantula et al. (2025) conducted an observational in Recent-onset atrial fibrillation (n=90). Three-channel photoplethysmography (PPG) armband with automated analysis vs. Ambulatory three-lead ECG (gold standard) was evaluated on Agreement in estimating atrial fibrillation burden (ICC 0.97-0.98, p=<0.001). A three-channel armband photoplethysmography device combined with an automated algorithm accurately estimated atrial fibrillation burden with excellent agreement (ICC 0.97-0.98) compared to a gold-standard ambulatory ECG.
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