Key result
Advanced oxidation protein products contribute to renal tubulopathy by inducing Elovl6, which increases stearic acid and causes tubular toxicity via ER stress.
Why the study?
Renal proximal tubulopathy is crucial in kidney disease, but its molecular mechanism and the role of altered renal fatty acid composition remain incompletely understood.
Population
Mice with cisplatin-induced nephrotoxicity, 5/6-nephrectomized mice, and HK-2 human tubular epithelial cells
Design
Preclinical in vivo and in vitro animal and cell study
Authors
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Elovl6 inhibition merits testing in preclinical CKD models; leaves open translation to human tubulopathy therapy.
AOPPs contribute to renal tubulopathy by perturbing renal fatty acids through the induction of Elovl6, suggesting a potential therapeutic target.
Imafuku et al. (2020) studied Renal tubulopathy. Elovl6 modulation and AOPPs was evaluated on Renal tubulopathy, ER stress, and inflammation. Advanced oxidation protein products contribute to renal tubulopathy by inducing Elovl6, which increases stearic acid and causes tubular toxicity via ER stress.
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