Key result
Antibody-dependent enhancement via Fc receptors promotes viral internalization and exacerbates disease, presenting a major obstacle to vaccination and novel antiviral therapeutics.
This review highlights the mechanisms and challenges of antibody-dependent enhancement in viral infections, which complicates vaccine development and antiviral therapies.
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ADE warrants caution in vaccine and antiviral strategies; leaves open Fc receptor mitigation approaches for research.
Taylor et al. (2015) conducted a review in Viral infections. Antibody-dependent enhancement was evaluated. Antibody-dependent enhancement via Fc receptors promotes viral internalization and exacerbates disease, presenting a major obstacle to vaccination and novel antiviral therapeutics.
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