The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort

Figures

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  Figure 1. Brain Care Score.

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  Figure 2. Frequency distribution of the Brain Care Score and its components in the UKB Legend. (A) shows the frequency of the total Brain Care Score over the range 1 to 19 observed in participants of the UKB study; (B) shows the frequencies of scores from the individual components of the total Brain Care Score.

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  Figure 3. Association of Brain Care Score at baseline with incidence of dementia, stratified by age group at baseline Legend. The thick line is the mean relative hazard curve for dementia incidence over the range of the Brain Care Score on a logarithmic scale; the shaded areas correspond to the 95% confidence intervals. The risk curves were adjusted for sex assigned at birth and plotted relative to the median Brain Care Score (indicated by the arrow) in the respective age group.

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  Figure 4. Association of Brain Care Score at baseline with incidence of stroke, stratified by age group at baseline Legend. The thick line is the mean relative hazard curve for stroke incidence over the range of the Brain Care Score on a logarithmic scale; the shaded areas correspond to the 95% confidence intervals. The risk curves were adjusted for sex assigned at birth and plotted relative to the median Brain Care Score (indicated by the arrow) in the respective age group.

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  Figure 5. Cumulative incidence of dementia, stroke, and dementia or stroke at baseline, stratified by Brain Care Score quintile group Legend. The red line corresponds to the cumulative incidence of the low-scoring BCS group (1st quintile: total BCS scores from 1 to 9), the orange line corresponds to the middle three BCS quintiles (total BCS scores from 10 to 13), and the green line corresponds to the high-scoring BCS group (5th quantile, total BCS scores from 14 to 19).