Key result
A derived prognostic model for acute pulmonary embolism predicted in-hospital mortality with an AUC of 0.899, sensitivity of 89.7%, and specificity of 77.7%, showing higher accuracy than PESI.
Why the study?
The study aimed to explore risk factors for in-hospital mortality and derive a prognostic model for patients with APE in China.
Does a newly derived prognostic model accurately predict in-hospital mortality in Chinese patients with acute pulmonary embolism compared to PESI and sPESI?
Observational (n=813)
No
Does a newly derived prognostic model accurately predict in-hospital mortality in Chinese patients with acute pulmonary embolism compared to PESI and sPESI?
Effect estimate: AUC 0.899
A newly derived prognostic model using clinical and laboratory variables accurately predicts in-hospital mortality in Chinese patients with acute pulmonary embolism, outperforming PESI and sPESI.
May aid risk stratification in Chinese APE patients; leaves open external validation before broader use.
INTRODUCTION: We aim to explore the risk factors for in-hospital mortality and to derive a prognostic model for patients with APE in China. MATERIALS AND METHODS: Inpatients with APE were enrolled from West China Hospital between January 2016 and December 2019. Logistic regression analyses were used to explore risk factors for in-hospital mortality and develop a prognostic model. RESULTS: A total of 813 subjects with APE were included in this study, of whom 542 were in the training set and 271 were in the test set. Multivariable regression analyses indicated that age, male, heart rate, systolic blood pressure, elevated NT-proBNP or troponin T, malignancy, chronic renal insufficiency, and respiratory failure were independent risk factors for in-hospital mortality. For the training set, the area under the curve (AUC) of the ROC curve was 0.899, with a sensitivity and specificity of 89.7% and 77.7%, respectively. The model had higher prediction accuracy than the PESI and sPESI. CONCLUSIONS: The prediction model has proven excellent discrimination and calibration, which may be a useful tool to help physicians make decisions regarding the best treatment strategy.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2022) conducted an observational in Acute Pulmonary Embolism (n=813). Prognostic model for in-hospital mortality vs. PESI and sPESI was evaluated on In-hospital mortality (AUC 0.899). A derived prognostic model for acute pulmonary embolism predicted in-hospital mortality with an AUC of 0.899, sensitivity of 89.7%, and specificity of 77.7%, showing higher accuracy than PESI.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: