Key result
In ovariectomized spontaneously hypertensive rats, oestradiol substitution restored the beneficial effect of moexipril on systolic blood pressure (-30 +/- 5 mmHg) and relative heart weight (-11 +/- 3%).
Estrogen replacement is permissive for the beneficial effects of ACE inhibition on blood pressure and cardiac hypertrophy in female spontaneously hypertensive rats.
Estrogen may modulate ACE inhibitor efficacy in hypertensive models; leaves open whether similar interactions apply in postmenopausal women.
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Pelzer et al. (2002) studied Cardiac hypertrophy and hypertension. 17beta-oestradiol and moexipril vs. Moexipril alone in ovariectomized rats was evaluated on Systolic blood pressure and relative heart weight. In ovariectomized spontaneously hypertensive rats, oestradiol substitution restored the beneficial effect of moexipril on systolic blood pressure (-30 +/- 5 mmHg) and relative heart weight (-11 +/- 3%).
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