Key result
Myocardial leukocytes modulate cardiac homeostasis and post-injury structural remodeling.
Why the study?
The myocardium contains diverse resident and nonresident leukocytes that regulate homeostasis and adaptation to injury, but a comprehensive overview of all major myocardial leukocyte classes was needed.
A fundamental understanding of cardiac immunology is critical, as resident and recruited immune cells represent promising pharmacological targets for preventing and treating cardiovascular disease and heart failure.
Should not yet alter clinical management of myocardial injury; extends literature on leukocyte functions but leaves therapeutic translation open.
The mammalian heart is characterized by the presence of striated myocytes, which allow continuous rhythmic contraction from early embryonic development until the last moments of life. However, the myocardium contains a significant contingent of leukocytes from every major class. This leukocyte pool includes both resident and nonresident immune cells. Over recent decades, it has become increasingly apparent that the heart is intimately sensitive to immune signaling and that myocardial leukocytes exhibit an array of critical functions, both in homeostasis and in the context of cardiac adaptation to injury. Here, we systematically review current knowledge of all major leukocyte classes in the heart, discussing their functions in health and disease. We also highlight the connection between the myocardium, immune cells, lymphoid organs, and both local and systemic immune responses.
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Cohen et al. (2023) conducted a review in Cardiac homeostasis and myocardial injury. Myocardial immune cells was evaluated. Myocardial leukocytes, including both resident and recruited immune cells, exhibit critical functions in maintaining cardiac homeostasis and modulating structural remodeling following myocardial injury.
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