Key result
Review highlights the diagnostic and therapeutic value of diverse cardiac immune cell populations.
Why the study?
The function and significance of diverse cardiac immune cell populations in health, aging, and disease remain incompletely understood despite their diagnostic and therapeutic importance.
This review highlights the diagnostic and therapeutic significance of immune cell populations in cardiac homeostasis and disease, providing relevant biological concepts for practicing pathologists.
May guide pathologic assessment of cardiac immune infiltrates; leaves open whether targeting subsets improves outcomes.
Immune cells play key roles in cardiac homeostasis and disease. Although the function and significance of diverse immune cell populations in the heart in health, aging, and in disease is not fully understood, it is clear that these immune populations can be of diagnostic and therapeutic significance. The field of cardio-immunology is vast and evolving constantly. Herein, we aim to focus on a subset of the immune cells that are abundant and significant in healthy and diseased heart, providing relevant biological concept and clinical implications for practicing pathologists.
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Axelrod et al. (2026) conducted a review in Cardiac homeostasis and disease. Immune cells was evaluated. This review highlights the diagnostic and therapeutic significance of diverse immune cell populations in the healthy and diseased heart, providing clinical implications for practicing pathologists.
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