What does this research mean for the field?

One-stage thoracoscopic resection for synchronous bilateral pulmonary nodules significantly reduces operative time, hospital stay, and costs compared to two-stage surgery, without increasing morbidity. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to determine the optimal surgical approach for synchronous bilateral pulmonary nodules by comparing one-stage and two-stage resections.

January 21, 2026Frontiers in SurgeryOpen Access

One-stage vs. two-stage thoracoscopic surgery for synchronous bilateral pulmonary nodules: a systematic review and meta-analysis

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Authors

RORachid Eduardo Noleto da Nóbrega OliveiraHospital de Câncer de Barretos GMGuilherme Franceschini MachadoAOL (United States)ISIsabella Cabianca Moriguchi Caetano SalvadorAnhembi Morumbi University

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Implication

Systematic review evaluates one-stage versus two-stage surgery efficiency in patients with bilateral nodules, indicating potential benefits of a single-anesthetic approach.

Key Points

The aim is to determine the optimal surgical approach for synchronous bilateral pulmonary nodules by comparing one-stage and two-stage resections.
Conducted a systematic review and meta-analysis of ten observational studies.
Included 1,015 adult patients undergoing pulmonary resections.
Analyzed continuous and binary outcomes using DerSimonian and Laird random-effects models in R.
One-stage resection reduced operative time by 24.36 minutes (95% CI -40.59 to -8.13).
Hospital stays were 2.79 days shorter for one-stage procedures (95% CI -4.25 to -1.33).
Direct surgical costs decreased by $5,543.73 (95% CI -6,601.05 to -4,486.40) in the one-stage group.

Cite This Study

Oliveira et al. (2026) studied this question.

synapsesocial.com/papers/6a21673a18635152c357de8f https://doi.org/10.3389/fsurg.2025.1755084

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Implication

Systematic review evaluates one-stage versus two-stage surgery efficiency in patients with bilateral nodules, indicating potential benefits of a single-anesthetic approach.

One-stage vs. two-stage thoracoscopic surgery for synchronous bilateral pulmonary nodules: a systematic review and meta-analysis

Discussion

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Implication

Key Points

Cite This Study

One-stage vs. two-stage thoracoscopic surgery for synchronous bilateral pulmonary nodules: a systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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