Key result
Recurrent syncope at rest in an 87-year-old man with moderate-severe aortic stenosis was attributed to postprandial hypotension from Alzheimer's-induced hyperorality rather than valvular obstruction.
Why the study?
Aortic stenosis can present atypically, and the association between syncope at rest and hyperorality in this setting has not been previously established.
Case Report (n=1)
Syncope at rest in patients with aortic stenosis should prompt investigation for non-valvular etiologies such as postprandial hypotension or arrhythmias.
Answers are grounded in this paper and cite their sources.
May prompt evaluation for postprandial hypotension in resting syncope with aortic stenosis; hypothesis-generating for non-valvular mechanisms in dementia.
Aortic stenosis is a common valvular pathology and may also have atypical presentations outside the classic triad of chest pain, syncope, and shortness of breath. Some patients may not present with the symptoms of the triad. This patient instead presented with syncope and vomiting. Statistically, the most common cause of syncope at rest in the setting of aortic stenosis is due to an arrhythmia rather than the valve itself limiting cardiac output. In a comorbid Alzheimer's patient who has developed hyperorality, postprandial hypotension can also result in syncope at rest. Therefore, syncope at rest should raise alarm for nonvalvular etiologies such as arrhythmia. This case study also aims to establish an association between syncope at rest and hyperorality in the setting of aortic stenosis, a first study so far. Additionally, it highlights an unusual presentation of aortic stenosis where syncope occurs at rest associated with vomit in the absence of chest pain or shortness of breath.
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Maharaj et al. (2023) conducted a case report in Aortic stenosis, syncope (n=1). Postprandial hypotension was evaluated. Recurrent syncope at rest in an 87-year-old man with moderate-severe aortic stenosis was attributed to postprandial hypotension from Alzheimer's-induced hyperorality rather than valvular obstruction.
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