Key result
Straight or lordotic thoracic spine in progressive muscular dystrophy was associated with a significantly higher incidence of mitral valve prolapse compared to a kyphotic spine (p<0.001).
Why the study?
Are geometrical changes of the thorax and heart associated with the development of mitral valve prolapse in patients with progressive muscular dystrophy?
Cross-Sectional (n=58)
Are geometrical changes of the thorax and heart associated with the development of mitral valve prolapse in patients with progressive muscular dystrophy?
p-value: p=<0.001
In patients with progressive muscular dystrophy, forward bending of the thoracic spine and subsequent flattening of the thorax compress the heart, leading to smaller LA/LV dimensions and redundancy of the mitral chordae, resulting in MVP.
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Thoracic geometry may link to MVP in muscular dystrophy; cross-sectional data leaves causality open for prospective study.
Yoshimitsu Yazawa (1984) conducted a cross-sectional in Progressive muscular dystrophy (n=58). Straight or lordotic thoracic spine vs. Kyphotic thoracic spine was evaluated on Incidence of mitral valve prolapse (p=<0.001). Straight or lordotic thoracic spine in progressive muscular dystrophy was associated with a significantly higher incidence of mitral valve prolapse compared to a kyphotic spine (p<0.001).
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