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This research investigates how cultured astrocytes and C6 glioma cells produce signaling molecules that affect immune responses.

December 1, 1982The Journal of ImmunologyOpen Access

Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.

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Randomized trial demonstrates prostaglandin E and IL-1-like factor production in astrocytes, suggesting immune interaction.

This research investigates how cultured astrocytes and C6 glioma cells produce signaling molecules that affect immune responses.
Cultured murine astrocytes treated with lipopolysaccharide (LPS) were analyzed for prostaglandin E release.
C6 glioma cells were evaluated for the secretion of an IL-1-like factor.
Thymocyte proliferation assays were conducted to assess the biological effects of these factors.
Astrocytes released significant prostaglandin E after LPS treatment, inhibiting C3H/HeJ thymocyte response to mitogen.
An IL-1-like factor from glia enhanced thymocyte proliferation but had no IL-2 activity.
The IL-1-like mediator was determined to have a molecular weight between 13,500 and 18,000.

Fontana et al. (1982) studied this question.

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