Carbon-Carbon Bond Formation in Heterocycles Using Ni- and Pd-Catalyzed Reactions

Methods for the formation of C-C bonds in heterocycles which occur via Ni- and Pd-catalyzed cross-coupling, alkenylation and alkynylation reactions are summarized. The influence of the organometallic-component and the nature of the catalyst on the efficiency of cross-coupling reactions are analyzed, and the scope of the reaction is established. 1. Introduction 2. Cross-Coupling Reactions with Heterocyclic Organometallics and Halides 2.1. Organolithium, Organomagnesium and Organozinc Compounds 2.2. Organomercuric and Organocopper Compounds 2.3. Organoboron, Organoaluminum and Organozirconium Compounds 2.4. Organotin Compounds 3. Reactions of Heteroaryl Halides with Alkenes and Alkynes 3.1. Reactions with Alkenes 3.2. Reactions with Alkynes 4. Other Reactions