Enhanced 4D flow MRI segmentation showed modestly improved correlation with 2D phase contrast MRI for quantifying pulmonary regurgitant fraction (r = 0.77, p = 0.002) in patients with tetralogy of Fallot.
Cross-Sectional (n=18)
No
Effect estimate: r = 0.77
p-value: p=0.002
Background 2D phase contrast (PC) MRI provides reliable quantification of blood flow in pts with tetralogy of Fallot (TOF). While 2D PC is the standard for evaluating pulmonary regurgitant fraction, it is limited by single direction velocity measurement and may be inadequate to characterize 3D hemodynamics. Multiple planar acquisitions are often required. While 4D flow MRI provides simultaneous assessment of 3D flow characteristics of all vessels within a volume and offers the ability to retrospectively quantify blood flow parameters at selectable regions of interest, these exams require substantial postprocessing and adjacent structures may be difficult to analyze. We compared traditional 2D PC and 4D flow quantification in patients with TOF using both traditional and enhanced segmentation techniques.
Robinson et al. (Wed,) conducted a cross-sectional in Tetralogy of Fallot with pulmonary regurgitation (n=18). 4D flow MRI with enhanced segmentation vs. Traditional 2D phase contrast (PC) MRI was evaluated on Correlation of pulmonary regurgitant fraction between enhanced 4D flow and 2D PC MRI (r = 0.77, p=0.002). Enhanced 4D flow MRI segmentation showed modestly improved correlation with 2D phase contrast MRI for quantifying pulmonary regurgitant fraction (r = 0.77, p = 0.002) in patients with tetralogy of Fallot.