A free-breathing 3D MRI protocol for morphology, function, and flow was technically feasible in all 5 patients with congenital heart disease, completing in an average of 29 minutes with adequate image quality.
Observational (n=5)
Single-blind (assessors)
No
Does unsupervised free-breathing 3-dimensional MR imaging provide comparable image quality and quantitative volumetric/flow data to conventional 2D imaging in patients with congenital heart disease?
A pilot study describing a comprehensive free-breathing 3D MRI protocol for congenital heart disease under 30 minutes, though results are not reported in the abstract.
Absolute Event Rate: 1.6% vs 1.5%
Methods Five patients with CHD were included in this pilot study (table 2 in Figure 2). The FB MR studies were performed on a Philips Acheiva 1.5T magnet using a 5-channel phased array coil (see Table 1 in Figure 1) 1. Respiratory synchronized 1, time-resolved MRA 2. Equilibrium phase MRA 3. 3D cine SSFP 4.4D phase contrast (PC) flow imaging 5.3D whole-heart single phase SSFP (coronary) Comparative data was obtained using conventional 2D cine RT SSFP sequences 2 in the VLA, 4 chamber and short axis planes, and 2D PC imaging. Data Analysis: Image quality assessment and quantitative volumetric and flow analysis were performed by three blinded, experienced users. MRA images were graded using a semi-quantitative scale from 1-5 for relevant imaging targets in CHD 1, with 1: excellent, no limitations, and 5: non-diagnostic. The clinical scoring system for 2D and 3D cine SSFP was based on bloodmyocardial contrast, endocardial edge definition and inter-slice alignment 2. Paired t-test analysis was performed on LV and RV volumes obtained by an experienced observer using the same software
Krishnamurthy et al. (Wed,) conducted a observational in Congenital heart disease (n=5). Free-breathing 3D MRI protocol vs. Conventional 2D MRI sequences was evaluated on Clinical score for image quality (1=excellent to 5=non-diagnostic). A free-breathing 3D MRI protocol for morphology, function, and flow was technically feasible in all 5 patients with congenital heart disease, completing in an average of 29 minutes with adequate image quality.