Key result
Transient, local assembly of NM2A pulses occurs in the cortical cytoskeleton of single adherent cells, specifically requiring the head domain of NM2A, kinase activity, and cytosolic calcium.
Pulsatile contractions in the cortical cytoskeleton are an intrinsic property of the NM2A motor head domain, independent of developmental signaling cues.
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No immediate clinical implications; leaves open whether NM2A pulsatility drives cardiovascular cell behaviors in vivo.
Baird et al. (2016) studied this question. Nonmuscle myosin 2A (NM2A) was evaluated on Transient, local assembly of NM2A pulses in the cortical cytoskeleton. Transient, local assembly of NM2A pulses occurs in the cortical cytoskeleton of single adherent cells, specifically requiring the head domain of NM2A, kinase activity, and cytosolic calcium.
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