Key result
Pressure overload-induced mild cardiac hypertrophy in rats reduces the transmural gradient of mitochondrial complex IV activity, primarily by lowering activity in the sub-epicardium.
This commentary highlights that transmural region-dependent mitochondrial dysfunction, particularly affecting the sub-epicardium, precedes overt ventricular failure in non-ischemic remodeling.
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Haynes et al. (2014) conducted an editorial in Cardiac hypertrophy. Pressure overload vs. Sham was evaluated on Transmural gradient of mitochondrial respiratory chain complex IV activity. Pressure overload-induced mild cardiac hypertrophy in rats reduces the transmural gradient of mitochondrial complex IV activity, primarily by lowering activity in the sub-epicardium.
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