Ring Expansion of 3‐Oxetanone‐Derived Spirocycles: Facile Synthesis of Saturated Nitrogen Heterocycles

One ring to bring them all: 4,5-Spirocycles derived from 3-oxetanone and β-heteroatom-substituted amino compounds undergo a Lewis acid mediated reaction cascade to form saturated nitrogen heterocycles. The unique reactivity of 3-oxetanone facilitates access to biologically important morpholines, piperazines, and thiomorpholines with an otherwise difficult-to-access substitution pattern from readily available starting materials. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.