January 1, 2009Nicotine & Tobacco Research
Are current smokers paradoxically protected against atrial fibrillation after cardiac surgery?
Key result
Current smoking was associated with a lower incidence of postoperative atrial fibrillation compared to nonsmokers (20% vs. 27%, p<0.001).
Why the study?
Does current smoking prevent postoperative atrial fibrillation in patients undergoing coronary artery bypass and valvular procedures?
Population
3,245 patients undergoing coronary artery bypass and valvular procedures
Comparison
Current smoking status vs Nonsmoking individuals
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
Smoking cessation counseling should remain unchanged; observational data leave open a paradoxical inverse association with postoperative atrial fibrillation.
Study Design
Type
Cohort (n=3,245)
Structured PICO
Does current smoking prevent postoperative atrial fibrillation in patients undergoing coronary artery bypass and valvular procedures?
P
Population
3,245 patients undergoing coronary artery bypass and valvular procedures evaluated for predictors of postoperative atrial fibrillation.
E
Exposure
Current smoking status
C
Comparator
Nonsmoking individuals
O
Outcome
Postoperative atrial fibrillation (AF)
Main Result
Odds Ratio: 0.54 (95% CI 0.34–0.87)
Absolute Event Rate: 20% vs 27%
p-value: p=0.011
Current smoking is paradoxically associated with a reduced risk of postoperative atrial fibrillation after cardiac surgery, particularly in patients not requiring inotropic support.
Cite This Study
Mariscalco et al. (2009) conducted a cohort in Postoperative atrial fibrillation (n=3,245). Current smoking vs. Nonsmoking was evaluated on Postoperative atrial fibrillation (OR 0.54, 95% CI 0.34-0.87, p=0.011). Current smoking was associated with a lower incidence of postoperative atrial fibrillation compared to nonsmokers (20% vs. 27%, p<0.001).