Hepatic lipid peroxidation in vivo in rats with chronic iron overload.

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This study aims to investigate lipid peroxidation in the liver of rats experiencing chronic iron overload.
Rats were administered ferric nitrilotriacetate (FeNTA) and carbonyl iron to induce chronic iron overload.
Biochemical and histologic evaluations were performed to assess hepatic iron concentrations and lipid peroxidation.
Mean hepatic iron concentrations were measured to correlate with conjugated diene formation.
Mitochondrial lipid peroxidation was observed at all iron concentration levels studied (1,197, 3,231, and 4,216 µg Fe/g).
Increased microsomal conjugated diene formation occurred only at the highest iron concentration (4,161 µg Fe/g).
Histological evaluation revealed excessive iron distribution in hepatocytes and Kupffer cells depending on the iron source.

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Finds evidence of lipid peroxidation in liver due to chronic iron overload, indicating potential cellular injury mechanisms.

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Bacon et al. (1983) studied this question.

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