Key result
High fat diet in rats increases transaminases, triglycerides, iron, and hepcidin but lowers ferritin.
Why the study?
The role of hepcidin expression and iron metabolism impairment in the early stages of liver inflammatory injury and NAFLD progression was unclear.
Does a high fat diet alter hepcidin gene expression and biochemical parameters in albino rats?
Does a high fat diet alter hepcidin gene expression and biochemical parameters in albino rats?
Increased exposure to fatty acids subverts hepatic iron metabolism, suggesting hepcidin may serve as an early marker for NAFLD.
High-fat diet perturbs iron markers in rats; hypothesis-generating for hepcidin in NAFLD, requiring human validation before any clinical inference.
The regulation of lipid metabolism is one of the liver's core functions.Fatty liver accumulation, inflammatory process and insulin resistance have been involved in the development and progression of non-alcoholic fatty liver disease (NAFLD), however resulting findings pointed an important role also for iron overload and triglyceride accumulation.In this study, we investigate the relative expression of hepcidin in addition to several biochemical parameters in the onset of steatosis to understand whether its impairment could be an early event of liver inflammatory injury.Sixteen rats were divided into two groups eight per each ,one group fed with normal diet and the other with high fat diet (HFD) for 6 weeks, after which serum lipid profile, transaminases levels, iron and ferritin were evaluated, in addition to hepcidin mRNA quantitation.In HFD fed rats, an increased serum transaminases levels, triglyceride and iron in comparison with the control group, associated with the increase in hepcidin relative expression and ferritin decreased level.In conclusion, the current study suggests that increased exposure to fatty acids subverts hepatic iron metabolism, favouring the induction of iron and hepcidin expression, so, hepcidin may serve as a marker for better diagnosing and monitoring NAFLD in early stages in order to avoid progression of the disease.
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A 2016 study studied Non-alcoholic fatty liver disease (NAFLD) (n=16). High fat diet (HFD) vs. Normal diet was evaluated on Serum lipid profile, transaminases levels, iron, ferritin, and hepcidin mRNA quantitation. High fat diet in rats increased serum transaminases, triglycerides, iron, and hepcidin relative expression, while decreasing ferritin levels compared to a normal diet.
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