Key result
Residence in Northern Finland was associated with a higher prevalence of pre-eclampsia compared with Southern Finland (13.9% vs 7.9%; adjusted OR 1.70, 95% CI 1.21-2.38, P=0.002).
Cross-Sectional (n=3,650)
Yes
Pre-eclampsia prevalence varies significantly by region in Finland, being highest in the North, which is only partially explained by regional differences in traditional CAD risk factors.
Answers are grounded in this paper and cite their sources.
Regional pre-eclampsia variation may reflect unmeasured factors; hypothesis-generating and requires prospective studies before informing practice.
AIMS: The aim of this study was to examine the prevalence of pre-eclampsia in Southern, Eastern, and Northern Finland, and the relationship between history of pre-eclampsia and maternal coronary artery disease (CAD) risk factors. METHODS AND RESULTS: Women aged 25-64 years, who participated in a cross-sectional population survey and had been pregnant (n=3650), were studied. The proportion of women who had ever had pre-eclampsia was lower in Southern (7.9%) compared with Northern Finland (13.9%) (P=0.001), but did not differ from Eastern Finland (11.1%). In the logistic regression model, the age-adjusted prevalence of pre-eclampsia was 1.92-fold in Northern (95% CI: 1.46-2.53, P<0.001) and 1.47-fold in Eastern Finland (95% CI: 1.11-1.96, P=0.008) compared with Southern Finland. The odds ratios (ORs) were 1.70 (95% CI: 1.21-2.38, P=0.002) and 1.16 (95% CI: 0.82-1.64, P=0.40), respectively, when adjusted for age at first birth, current age, parity, body mass index (BMI), increased blood cholesterol, hypertension, diabetes/impaired glucose tolerance, CAD, and mother's myocardial infarction. History of pre-eclampsia was associated with increased blood cholesterol, higher current BMI and blood pressure, and higher current prevalence of hypertension, diabetes/impaired glucose tolerance. CONCLUSIONS: Pre-eclampsia is most prevalent in the Northern part of Finland and could only be partly explained by higher prevalence of CAD risk factors.
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Kaaja et al. (2004) conducted a cross-sectional in Pre-eclampsia (n=3,650). Residence in Northern Finland vs. Residence in Southern Finland was evaluated on Prevalence of pre-eclampsia (OR 1.70, 95% CI 1.21-2.38, p=0.002). Residence in Northern Finland was associated with a higher prevalence of pre-eclampsia compared with Southern Finland (13.9% vs 7.9%; adjusted OR 1.70, 95% CI 1.21-2.38, P=0.002).
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