Why the study?
Do pulmonary artery occlusion pressure and central venous pressure correlate with ventricular filling volume and cardiac performance in response to volume infusion in normal healthy volunteers?
Population
44 normal healthy volunteers (n=12 in group 1, n=32 in group 2)
Design
Cohort, nonrandomized, nonblinded
Follow-up
3 hours
Authors
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Questions use of CVP/PAOP to guide volume in normals; hypothesis-generating for critically ill patients.
Do pulmonary artery occlusion pressure and central venous pressure correlate with ventricular filling volume and cardiac performance in response to volume infusion in normal healthy volunteers?
Central venous pressure and pulmonary artery occlusion pressure are poor predictors of ventricular preload and cardiac performance in normal subjects, challenging their traditional utility for optimizing hemodynamics.
Kumar et al. (2004) studied this question.
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