Key result
The ecNOS4a allele was associated with significantly lower flow-mediated vasodilation in patients with Type 2 diabetes (P<0.05), acting as an independent risk factor especially in smokers.
Why the study?
Does the ecNOS4a allele reduce endothelium-dependent vasodilation in patients with Type 2 diabetes?
Population
95 patients with Type 2 diabetes
Comparison
Presence of ecNOS4a allele vs Absence of ecNOS4a allele (genotype 4b/b)
Design
Cross-sectional
Authors
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May flag endothelial risk in diabetic smokers; leaves open prospective validation before clinical use.
Cross-Sectional (n=95)
Does the ecNOS4a allele reduce endothelium-dependent vasodilation in patients with Type 2 diabetes?
p-value: p=<0.05
Komatsu et al. (2002) conducted a cross-sectional in Type 2 diabetes (n=95). ecNOS4a allele vs. Absence of ecNOS4a allele was evaluated on Flow-mediated (endothelium dependent, FMD) vasodilation (p=<0.05). The ecNOS4a allele was associated with significantly lower flow-mediated vasodilation in patients with Type 2 diabetes (P<0.05), acting as an independent risk factor especially in smokers.
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