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January 31, 2025NutrientsOpen Access

Metabolic Syndrome in the Amazon: Customizing Diagnostic Methods for Urban Communities

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Key result

A diagnostic model combining VLDL-C and SBP detects metabolic syndrome with ~92% sensitivity.

  • Sensitivity 91.6%, Specificity 78.5%
  • n=251

Why the study?

Metabolic syndrome is a significant public health issue in urbanizing regions like the Peruvian Amazon, motivating the development and validation of a simple, cost-effective diagnostic model for early detection.

Does a diagnostic model combining very-low-density lipoprotein cholesterol and systolic blood pressure accurately detect metabolic syndrome in adults in resource-limited urban settings?

Population

251 adults aged over 18 years in San Juan Bautista, Iquitos

Design

Cross-sectional study

Authors

JAJosé Manuel Alcaide-LeyvaMRManuel Romero‐SaldañaMGMaría Helena García-Rodríguez

Discussion

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Overview

May aid low-cost screening in resource-limited settings; leaves open prospective validation before adoption.

Study Design

Type

Cross-Sectional (n=251)

Structured PICO

Does a diagnostic model combining very-low-density lipoprotein cholesterol and systolic blood pressure accurately detect metabolic syndrome in adults in resource-limited urban settings?

P
Population
251 adults aged over 18 years from the urban community of San Juan Bautista, Iquitos, evaluated for metabolic syndrome.
E
Exposure
Diagnostic model combining very-low-density lipoprotein cholesterol and systolic blood pressure
O
Outcome
Diagnostic accuracy (sensitivity and specificity) for early detection of metabolic syndrome

Main Result

Effect estimate: Sensitivity 91.6%, Specificity 78.5%

A simple diagnostic model using VLDL cholesterol and systolic blood pressure offers a practical, low-cost tool for early detection of metabolic syndrome in resource-limited urban settings.

Limitations

  • small sample size
  • lack of external validation

Cite This Study

Alcaide-Leyva et al. (2025) conducted a cross-sectional in Metabolic syndrome (n=251). Diagnostic model combining very-low-density lipoprotein cholesterol and systolic blood pressure was evaluated on Detection of metabolic syndrome (Sensitivity 91.6%, Specificity 78.5%). A diagnostic model combining very-low-density lipoprotein cholesterol and systolic blood pressure detected metabolic syndrome with a sensitivity of 91.6% and a specificity of 78.5%.

synapsesocial.com/papers/6a217aa3df884daff757f612https://doi.org/10.3390/nu17030538
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Harmonizing the Metabolic Syndrome2009 · 14,973 citations
  2. 2The FINDRISC questionnaire capacity to predict diabetes mellitus II, arterial hypertension and comorbidity in women from low-and-middle-income countries2019 · 12 citations
  3. 3Metabolic syndrome—a new world‐wide definition. A Consensus Statement from the International Diabetes Federation2006 · 6,650 citations
  4. 4Role of Insulin Resistance in Human Disease1988 · 12,160 citations
  5. 5Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge1972 · 32,626 citations