Optimizing Bone Cuts Enhances Predicted Bone Union Propensity in Mandibular Body Reconstruction

Reconstructing the mandible after the surgical removal of diseased sections is crucial for restoring functions such as chewing, speech, and facial integrity. However, achieving consistent bone union remains a significant challenge. This study hypothesizes that optimizing donor bone cuts, specifically through improved positioning and cut plane orientation, can enhance bone union. To test this hypothesis, we present a novel workflow that leverages Bayesian optimization. Applied to a mandibular body defect case, this approach integrates virtual reconstruction, remeshing, and biomechanical simulation, achieving up to a 75% increase in predicted bone union propensity during a chewing cycle. Our findings indicate that donor cut planes warrant greater emphasis in surgical plan-ning. Furthermore, optimization underscores the potential of this patient-specific, data-driven method to advance bone healing in mandibular reconstruction.