Key result
Patients with ischemic stroke had significantly lower serum vitamin B12 levels (184.98 picomol/L) compared to healthy controls (639.62 picomol/L).
Why the study?
Hyperhomocysteinemia is an independent risk factor for stroke and vitamin B12 is essential to homocysteine metabolism, motivating evaluation of vitamin B12 levels alongside hypertension, diabetes, and smoking status.
Is lower serum vitamin B12 level associated with ischemic stroke?
Case-Control (n=90)
No
Is lower serum vitamin B12 level associated with ischemic stroke?
Mean Difference: 454.64
Absolute Event Rate: 184.98% vs 639.62%
p-value: p=<0.001
Lower serum vitamin B12 levels are associated with ischemic stroke, particularly in patients with hypertension, diabetes, or a history of smoking.
Lower B12 levels were associated with ischemic stroke; hypothesis-generating and requires prospective studies before any clinical action.
Background: Hyperhomocysteinemia has been reported to be an independent risk factor for the development of stroke. Vitamin B12 is an important element of homocysteine metabolism. Aims and Objective: To compare the vitamin B12 level among the groups and compare it with the presence of hypertension, diabetes and smoking status. Materials and Methods: Ninety subjects were studied in the Department of General Medicine at Sri Aurobindo Medical College and PGI, Indore (M. P.) for one and half year from June-2015 to March-2016 after dividing them in to Cases (n=45; patients of ischemic stroke) and Control (n=45; subjects with no documented stroke). After recording general information on smoking/alcohol habit, hypertension and diabetes status, serum vitamin B12 level was assessed in all the subjects. Results: Vitamin B12 level (184.98±46.41 picomol/L) was greater in Case group as compared to Control group (639.62±157.43μmol/L) (p<0.001). Amongst those who had a stroke but had a habit of smoking/tobacco, had hypertension and diabetes diagnosed with very lowered vitamin B12 level (199.00±0.00 picomol/L, 176.00±31.21 picomol/L and 152.00±11.31 picomol/L) as compared to those without stroke. Tthose who had a stroke but had mixed diet had much lowered vitamin B12 level (188.71±54.63 picomol/L) as compared to control (592.69±143.71 picomol/L). Conclusion: Patients with stroke had lower level of vitamin B12 mainly in those with had a habit of smoking/tobacco, had hypertension, diabetes and had mixed diet as compared to those without stroke. Keywords: vitamin B12, stroke, hypertension, diabetes, smoking
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Singh et al. (2020) conducted a case-control in Ischemic stroke (n=90). Ischemic stroke vs. Healthy controls was evaluated on Serum Vitamin B12 level (MD 454.64, p=<0.001). Patients with ischemic stroke had significantly lower serum vitamin B12 levels (184.98 picomol/L) compared to healthy controls (639.62 picomol/L).
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