What question did this study set out to answer?

This research aims to compare the bias and accuracy of two hazard ratio estimators derived from the logrank test.

A comparison of two simple hazard ratio estimators based on the logrank test

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Simulation study compares two hazard ratio estimators, revealing differences in bias and accuracy.

This research aims to compare the bias and accuracy of two hazard ratio estimators derived from the logrank test.
Simulation study to evaluate the Pike and Peto hazard ratio estimators.
Assessment of bias and nominal coverage of confidence intervals with varying hazard ratios.
Evaluation of estimator performance based on the relative death rates.
The Pike estimator exhibited less bias than the Peto estimator across all tested scenarios.
Both estimators showed increased bias with hazard ratios greater than 3, with the Pike estimator delivering superior coverage.
For hazard ratios less than 3, usage of the Pike estimator is recommended to minimize bias.

Berry et al. (1991) studied this question.

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