Key result
Among 2,548 schoolchildren diagnosed with influenza, prior influenza vaccination was associated with a lower hospitalization rate compared to unvaccinated children.
Why the study?
Although influenza vaccine prevents symptom onset, its beneficial effects after vaccinated individuals become symptomatic remain undetermined.
Does influenza vaccination reduce fever duration, symptom frequency, and hospitalization in elementary schoolchildren diagnosed with influenza?
Observational (n=2,548)
Yes
Does influenza vaccination reduce fever duration, symptom frequency, and hospitalization in elementary schoolchildren diagnosed with influenza?
Influenza vaccination may reduce hospitalization rates in schoolchildren who develop influenza.
Supports potential benefit in reducing hospitalizations; hypothesis-generating and requires randomized confirmation before practice change.
Although influenza vaccine has been shown to prevent influenza symptom onset, its further beneficial effects after vaccinated individuals become symptomatic remain undetermined. This epidemiological survey compared influenza symptoms in subjects diagnosed with influenza who were and were not vaccinated. A prospective survey was performed among the 13,217 schoolchildren who attended all 29 public elementary schools in Matsumoto City, Nagano Prefecture, Japan, during the 2014/2015 influenza season. Information about symptoms and background demographic and clinical factors were obtained from a questionnaire. Of these schoolchildren, 2,548 were diagnosed with influenza and 1,122 were previously vaccinated and 1,426 were unvaccinated. Fever duration and frequency of symptoms and hospitalization were compared in vaccinated and unvaccinated children. The hospitalization rate was lower in vaccinated children, whereas symptom frequency and fever duration were similar in the two groups. This study showed that hospitalization was less in vaccinated children. Vaccination may attenuate symptom intensity after symptom onset.
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Uchida et al. (2020) conducted an observational in Influenza (n=2,548). Influenza vaccination vs. Unvaccinated was evaluated on Hospitalization rate, symptom frequency, and fever duration. Among 2,548 schoolchildren diagnosed with influenza, prior influenza vaccination was associated with a lower hospitalization rate compared to unvaccinated children.
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