Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 2, 2025Scientific ReportsOpen Access

Exploring the molecular mechanisms of comorbidity between thyroid cancer and breast cancer through multi-omics data

View Full Paper
Ask AI
Bookmark
Share

Authors

RYRui Juan YangJinan UniversityJLJiayi LiChina-Japan Friendship HospitalHZHongyang ZhangDalian Medical University

Discussion

Loading...

Member takes

Implication

Bioinformatics analysis reveals potential targets and mechanisms related to thyroid and breast cancers.

Key Points

  • This study explores the molecular connections between thyroid cancer and breast cancer, aiming to identify potential biomarkers and therapeutic targets.
  • Analyzed multi-omics datasets for differentially expressed genes using the limma package.
  • Employed weighted gene co-expression network analysis (WGCNA) to identify disease-related gene modules.
  • Constructed mRNA-miRNA regulatory networks and screened therapeutic agents via online tools.
  • Identified 58 overlapping differential genes associated with both cancers; 27 common genes from WGCNA were retained.
  • Discovered seven hub genes linked to autophagy and ferroptosis.
  • Screened six key regulatory miRNAs and identified six potential therapeutic agents.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/6a21828107d1ae53c45fab96https://doi.org/10.1038/s41598-025-06566-w
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The neurotransmitter calcitonin gene-related peptide shapes an immunosuppressive microenvironment in medullary thyroid cancer2024 · 76 citations
  2. 2KEGG: new perspectives on genomes, pathways, diseases and drugs2016 · 9,679 citations
  3. 3Identification and validation of potential common biomarkers for papillary thyroid carcinoma and Hashimoto’s thyroiditis through bioinformatics analysis and machine learning2024 · 7 citations
  4. 4Multi-omics analysis uncovered systemic lupus erythematosus and COVID-19 crosstalk2024 · 8 citations
  5. 5Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer2018 · 231 citations