Key result
Patent foramen ovale (PFO) was identified as an independent risk factor for cryptogenic ischemic stroke in young and middle-aged adults (OR 1.923).
Why the study?
The study was conducted to investigate the effect of atrial septal aneurysm and patent foramen ovale on cryptogenic ischemic stroke in young and middle-aged patients.
Are patent foramen ovale and atrial septal aneurysm independent risk factors for cryptogenic ischemic stroke in young and middle-aged patients?
Case-Control (n=288)
No
Are patent foramen ovale and atrial septal aneurysm independent risk factors for cryptogenic ischemic stroke in young and middle-aged patients?
Odds Ratio: 1.923 (95% CI 1.384–2.673)
Absolute Event Rate: 37.5% vs 10.42%
p-value: p=0.000
Patent foramen ovale (PFO) and PFO combined with atrial septal aneurysm (ASA) are independent risk factors for cryptogenic ischemic stroke in young and middle-aged patients.
Supports PFO screening consideration in young cryptogenic stroke patients; leaves open causal role and closure benefit pending randomized trials.
Objective: To investigate the effect of atrial septal aneurysm (ASA) and patent foramen ovale (PFO) on cryptogenic ischemic stroke in young and middle-aged patients. Methods: A case-control study was conducted to select 96 young and middle-aged patients with cryptogenic ischemic stroke in the Department of Neurology of our hospital from January 2015 to January 2020 (observation group). A total of 192 patients with non-ischemic stroke were selected as the control group. The clinicadata and transthoracic echocardiography (cTTE) results were compared between the two groups. Results: The ASA depth and tumor wall thickness in the observation group were 15.50 (12.40, 19.80) mm and 3.90 (2.80,4.50) mm, respectively, which were significantly higher than those in the control group (P < 0.05). Logistic regression analysis showed that PFO, and PFO combined with ASA were the influencing factors of cryptogenic ischemic stroke in middle-aged and young people OR = 1.923 and 1.384, P < 0.05). Conclusion: Atrial septal aneurysm combined with PFO and PFO are independent influencing factors factor for the occurrence of cryptogenic ischemic stroke in young and middle-aged people, which is worthy of further study.
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Ling et al. (2022) conducted a case-control in Cryptogenic ischemic stroke (n=288). Patent foramen ovale (PFO) vs. Absence of PFO was evaluated on Cryptogenic ischemic stroke (OR 1.923, 95% CI 1.384-2.673, p=0.000). Patent foramen ovale (PFO) was identified as an independent risk factor for cryptogenic ischemic stroke in young and middle-aged adults (OR 1.923).
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