Key result
Conduction system pacing significantly improved left ventricular ejection fraction from 23.2% to 34.93% in patients with heart failure and severely reduced ejection fraction.
Why the study?
The feasibility and outcomes of conduction system pacing in patients with heart failure and severely reduced LVEF under 30% were uncertain.
Does conduction system pacing improve clinical and echocardiographic outcomes in patients with heart failure and severely reduced ejection fraction (<30%)?
Observational (n=70)
No
Does conduction system pacing improve clinical and echocardiographic outcomes in patients with heart failure and severely reduced ejection fraction (<30%)?
Mean Difference: 11.73
Absolute Event Rate: 34.93% vs 23.2%
p-value: p=<0.001
Conduction system pacing is feasible, safe, and associated with significant clinical and echocardiographic improvements in heart failure patients with severely reduced ejection fraction (<30%).
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CSP-associated LVEF gains in severe HFrEF are hypothesis-generating; leaves open need for randomized outcome trials.
Ma et al. (2023) conducted an observational in Heart failure with severely reduced ejection fraction (n=70). Conduction system pacing vs. Baseline was evaluated on Left ventricular ejection fraction (LVEF) (p=<0.001). Conduction system pacing significantly improved left ventricular ejection fraction from 23.2% to 34.93% in patients with heart failure and severely reduced ejection fraction.
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