Why the study?
Does von Willebrand factor deficiency reduce atherosclerosis in LDLR-/- mice fed an atherogenic diet?
Does von Willebrand factor deficiency reduce atherosclerosis in LDLR-/- mice fed an atherogenic diet?
In a mouse model of atherosclerosis, von Willebrand factor deficiency reduced lesion size and altered distribution, highlighting its role in flow-dependent atherogenesis.
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Supports vWF in flow-dependent atherogenesis; hypothesis-generating for human translation, with clinical trials needed.
Methia et al. (2001) studied this question.
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