A region on chromosome 16 is associated with Doberman Pinscher dilated cardiomyopathy

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  Fig. 1. Results from case group vs. population controls. The Q–Q plot in the top left indicates adequate control for population stratification (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\lambda _{\textrm{GC}} \approx 1.05$$\end{document}λGC≈1.05). Manhattan plot reveals a signal on chromosome 16 (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$P_\textrm{spa} = {3.687\times {10}^{-6}}$$\end{document}Pspa=3.687×10-6, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$P_\textrm{raw} = {4.02\times {10}^{-7}}$$\end{document}Praw=4.02×10-7). Bottom panel highlights the window around this signal, including 100kb bands on either end. Signaled SNPs are shown…