A highly sensitive troponin T level of 3,466 ng/L or above showed 90% sensitivity and 90% specificity for the diagnosis of perioperative myocardial infarction after cardiac surgery.
Observational (n=413)
No
Does highly sensitive troponin T (hsTnT) measurement accurately diagnose perioperative myocardial infarction in patients undergoing cardiac surgery?
A highly sensitive troponin T cut-off of 3466 ng/L demonstrates high sensitivity and specificity for diagnosing perioperative myocardial infarction following cardiac surgery.
Effect estimate: 90% sensitivity and 90% specificity
Perioperative myocardial infarction (PMI) confers a considerable risk in cardiac surgery settings; finding the ideal biomarker seems to be an ideal goal. Our aim was to assess the diagnostic accuracy of highly sensitive troponin T (hsTnT) in cardiac surgery settings and to define a diagnostic level for PMI diagnosis. This was a single-center prospective observational study analyzing data from all patients who underwent cardiac surgeries. The primary outcome was the diagnosis of PMI through a specific level. The secondary outcome measures were the lengths of mechanical ventilation (LOV), stay in the intensive care unit (LOSICU), and hospitalization. Based on the third universal definition of PMI, patients were divided into two groups: no PMI (Group I) and PMI (Group II). Data from 413 patients were analyzed. Nine patients fulfilled the diagnostic criteria of PMI, while 41 patients were identified with a 5-fold increase in their CK-MB (≥ 120 U/L). Using ROC analysis, a hsTnT level of 3,466 ng/L or above showed 90% sensitivity and 90% specificity for the diagnosis of PMI. Secondary outcome measures in patients with PMI were significantly prolonged. In conclusion, the hsTnT levels detected here paralleled those of CK-MB and a cut-off level of 3466 ng/L could be diagnostic of PMI.
Omar et al. (Thu,) conducted a observational in Cardiac surgery (n=413). Highly sensitive troponin T (hsTnT) was evaluated on Diagnosis of perioperative myocardial infarction (PMI) (90% sensitivity and 90% specificity). A highly sensitive troponin T level of 3,466 ng/L or above showed 90% sensitivity and 90% specificity for the diagnosis of perioperative myocardial infarction after cardiac surgery.