Population
Cultured neonatal rat cardiac fibroblasts
Comparison
Neutral endopeptidase inhibitors combined with… vs Exogenous ANP alone or myocyte-conditioned…
Design
Preclinical
Authors
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NEP inhibitors may limit fibroblast collagen synthesis; leaves open translation to reduced remodeling in vivo.
NEP inhibitors enhance the paracrine inhibitory effect of endogenous ANP on collagen synthesis in cardiac fibroblasts, suggesting a mechanism for attenuating cardiac remodeling.
Maki et al. (2000) studied this question.
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