What question did this study set out to answer?

This research investigates how repeated cocaine administration influences the phosphorylation of CREB in the nucleus accumbens.

October 7, 2005Journal of Neurochemistry

Cocaine‐induced CREB phosphorylation in nucleus accumbens of cocaine‐sensitized rats is enabled by enhanced activation of extracellular signal‐related kinase, but not protein kinase A

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This research investigates how repeated cocaine administration influences the phosphorylation of CREB in the nucleus accumbens.
Rats underwent repeated cocaine administration to induce behavioral sensitization.
Western blots and immunohistochemistry measured phosphorylation levels of signaling kinases and CREB.
Unilateral infusions of pharmacological inhibitors U0126 and Rp-cAMPs assessed the contributions of ERK and PKA.
Cocaine administration increased CREB and ERK phosphorylation, but not CaMKs or GluR1 phosphorylation in sensitized rats.
Inhibition of ERK using U0126 reduced cocaine-induced ERK and CREB phosphorylation.
Inhibition of PKA using Rp-cAMPs did not affect CREB phosphorylation, highlighting ERK's crucial role.

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Implication

Randomized trial demonstrates enhanced ERK activation driving CREB phosphorylation in cocaine-sensitized rats, suggesting ERK's key role in cocaine's effects.

Cite This Study

Mattson et al. (2005) studied this question.

synapsesocial.com/papers/6a219147df884daff758056e https://doi.org/10.1111/j.1471-4159.2005.03500.x

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Implication

Randomized trial demonstrates enhanced ERK activation driving CREB phosphorylation in cocaine-sensitized rats, suggesting ERK's key role in cocaine's effects.

Cocaine‐induced CREB phosphorylation in nucleus accumbens of cocaine‐sensitized rats is enabled by enhanced activation of extracellular signal‐related kinase, but not protein kinase A

Key Points

Discussion

Implication

Cite This Study

Cocaine‐induced CREB phosphorylation in nucleus accumbens of cocaine‐sensitized rats is enabled by enhanced activation of extracellular signal‐related kinase, but not protein kinase A

Key Points

Discussion

Implication

Cite This Study

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