Key result
Lower ADAMTS13 activity is linked to the presence of deep medullary veins.
Why the study?
It was unknown whether circulating ADAMTS13 activity can offer insights into the mechanism of pathophysiological changes in deep medullary veins.
Cross-Sectional (n=262)
Reduced ADAMTS13 activity is inversely correlated with the severity of deep medullary veins in elderly individuals, suggesting a potential pathophysiological link.
Lower ADAMTS13 activity linked to DMV in elderly; hypothesis-generating for cerebral small vessel disease and requires prospective validation.
Objectives: This study aims to investigate whether circulating ADAMTS13 activity can offer insights into the mechanism of pathophysiological changes in deep medullary veins (DMVs). Methods: This study was conducted on a community cohort of elderly individuals in Shanghai. Plasma von Willebrand factor (VWF) levels and ADAMTS13 activity were measured. A validated DMV score described the overall burden of DMV on the brain. Through ordinal regression models, we investigated the correlation between VWF levels, ADAMTS13 activity, and increasing severity of DMV score while adjusting for demographics and cardiovascular risk factors. Results: The study enrolled 262 subjects according to the inclusion criteria. The mean VWF level (1.35 ± 0.25) was higher in the DMV group than in the group without DMV (1.25 ± 0.30) (p = 0.025), and ADAMTS13 activity (83.76 ± 7.96) was relatively lower. After adjusting for age, sex, alcohol consumption, smoking, hypertension, and diabetes, reduced ADAMTS13 activity [β = -7.78; 95 % CI (-10.21, -5.35) p < 0.01] was associated with DMV. Moreover, correlation analysis indicated that ADAMTS13 activity was negatively correlated with the DMV score (Kendall's tau-b = -0.53, p < 0.001). Discussion: In summary, there was an inverse correlation observed between ADAMTS13 activity and the DMV score, which may provide some clinical clues for exploring the potential pathogenesis of DMV.
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Sun et al. (2024) conducted a cross-sectional in Deep medullary veins (DMVs) (n=262). ADAMTS13 activity vs. Group without DMV was evaluated on Deep medullary vein (DMV) score (β -7.78, 95% CI -10.21, -5.35, p=<0.01). Reduced ADAMTS13 activity was significantly associated with the presence of deep medullary veins (β = -7.78; 95% CI -10.21 to -5.35; p<0.01).
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