January 1, 2005RNA Biology249 citationsOpen Access
View Full PaperHuR: Post-Transcriptional Paths to Malignancy
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Abstract
The RNA-binding protein HuR regulates the stability and translation of target mRNAs. While no HuR mutations have been found in cancer, a link between HuR and malignant transformation has been suggested in cancers of the breast, colon, lung and ovary. We describe a paradigm consistent with a central role of HuR in oncogenesis.