Key result
Prophylactic administration of antidepressants such as fluoxetine does not show efficacy in preventing post-stroke depression or improving other clinical indicators.
Why the study?
Post-stroke depression develops in one-third of stroke survivors and worsens prognosis, raising the question of whether early antidepressant therapy can prevent depression or improve outcomes.
Do antidepressants prevent or treat post-stroke depression in stroke survivors?
Do antidepressants prevent or treat post-stroke depression in stroke survivors?
Prophylactic use of antidepressants to prevent post-stroke depression is not justified, but SSRIs remain indicated for treating established post-stroke depression.
Does not justify prophylactic antidepressants post-stroke; leaves open targeted prevention trials while affirming treatment of established depression.
U tĹetiny pacientĹŻ pĹeĹživĹĄĂch cĂŠvnĂ mozkovou pĹĂhodu se rozvine deprese (post-stroke depression, PSD), kterĂĄ mĂĄ negativnĂ dopad na mortalitu, mĂru postiĹženĂ a celkovou prognĂłzu. ÄasnĂŠ zahĂĄjenĂ podĂĄvĂĄnĂ antidepresiv (AD) by tak mohlo pĹedejĂt rozvoji deprese, a tĂm (Äi souÄasnÄ) zlepĹĄit prognĂłzu pacientĹŻ i v dalĹĄĂch oblastech postiĹženĂ. SĂŠrie recentnĂch multicentrickĂ˝ch studiĂ s fluoxetinem vĹĄak neukazujĂ ĂşÄinnost ani v pĹedchĂĄzenĂ deprese, ani dalĹĄĂch klinickĂ˝ch ukazatelĂch. ProfylaktickĂŠ podĂĄvĂĄnĂ antidepresiv se tak v souÄasnosti jevĂ jako neodĹŻvodnÄnĂŠ. V lĂŠÄbÄ jiĹž rozvinutĂŠ deprese je i nadĂĄle podĂĄvĂĄnĂ AD (SSRI jako prvnĂ volba) indikovĂĄno a dosavadnĂ studie ukazujĂ stĹednÄ vĂ˝znamnĂ˝ ĂşÄinek, velkĂŠ a dlouhodobĂŠ studie jasnÄ doklĂĄdajĂcĂ ĂşÄinnost a bezpeÄnost AD nicmĂŠnÄ dosud chybĂ. SoubÄĹžnÄ rostoucĂ zĂĄjem o neurostimulaÄnĂ a psychosociĂĄlnĂ intervence tak naznaÄujĂ trend k multimodĂĄlnĂ lĂŠÄbÄ PSD.
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Tomáš Novák (2021) conducted a review in Post-stroke depression. Antidepressants was evaluated. Prophylactic administration of antidepressants such as fluoxetine does not show efficacy in preventing post-stroke depression or improving other clinical indicators.
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