Visual assessment of global chromatin intranuclear localization and its cellular diversification in mouse cells

DNA is the core that controls the life activities of cells. In eukaryotic cells, DNA is dispersedly packaged into multiple strands of chromatin to regulate cellular life activities, however, the underlying logic and significance of this configuration remain unclear. In mouse cells, pericentromeric satellite DNA from multiple strands of chromatin can aggregate to form chromocenters [1,2]. Based on microscopic imaging techniques and analysis, we further reveal that there is a non-random recombination aggregation between chromatin in different mouse nuclei, leading to differentiation of nuclear structure and correlation with cell function. We speculate that the recombination aggregation of chromatin nuclear localization can further enrich limited DNA genetic information, and its induced nuclear structural diversification is crucial for the formation of cellular diversification.