Key result
VNTR polymorphisms in the DRD4, DAT1, and 5-HTT genes were not significantly associated with obesity or differences in BMI among obese individuals.
Why the study?
Are VNTR polymorphisms in DRD4, 5-HTT, and DAT1 genes associated with obesity?
Case-Control (n=382)
Are VNTR polymorphisms in DRD4, 5-HTT, and DAT1 genes associated with obesity?
p-value: p=not statistically significant
VNTR polymorphisms in DRD4, 5-HTT, and DAT1 genes do not appear to be associated with obesity.
Does not warrant incorporating these variants into obesity risk assessment; leaves open contributions from other genetic or environmental factors.
OBJECTIVE: To investigate the association between VNTR polymorphisms of DRD4, DAT1 and 5-HTT genes and obesity. MATERIAL AND METHODS: Peripheral blood samples of 234 obese (BMI ≥ 30) and 148 healthy individuals (BMI ≤ 25) were objected to PCR to detect the VNTR of the 2nd intron of 5-HTT, 3rd exon of DRD4 and 3'UTR of DAT1 genes. RESULTS: The association between obesity and genotype distributions of 5-HTT, DAT1 and DRD4 genes and between obesity and distributions of allele frequencies were tested by Chi Square (χ(2)) test and were not found statistically significant. BMI values for genotype of obese and morbidly obese (BMI > 40) individuals were analyzed by Kruskal-Wallis and not found statistically significant differences between BMI values for the most frequent genotypes of 5-HTT, DAT1 and DRD4 genes. CONCLUSIONS: As a conclusion, there was no association between 5-HTT, DAT1 and DRD4 genes VNTR polymorphisms and obesity.
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Uzun et al. (2015) conducted a case-control in Obesity (n=382). VNTR polymorphisms of DRD4, DAT1 and 5-HTT genes vs. Healthy individuals (BMI ≤ 25) was evaluated on Association between obesity and genotype distributions of 5-HTT, DAT1 and DRD4 genes (p=not statistically significant). VNTR polymorphisms in the DRD4, DAT1, and 5-HTT genes were not significantly associated with obesity or differences in BMI among obese individuals.
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