Key result
Depression, but not anxiety, is linked to ~62% higher all-cause mortality in colorectal cancer.
Why the study?
Depression and anxiety are common in patients with colorectal cancer, but whether they are related to cancer mortality remains unclear.
Does depression or anxiety increase all-cause or cancer-specific mortality in patients with colorectal cancer?
Meta-Analysis (n=26,907)
Does depression or anxiety increase all-cause or cancer-specific mortality in patients with colorectal cancer?
Hazard Ratio: 1.62 (95% CI 1.27–2.06)
p-value: p=<0.00001
Depression, but not anxiety, is an independent predictor of increased all-cause mortality in patients with colorectal cancer, highlighting the importance of early detection and treatment of mental disorders in this population.
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May warrant depression screening in colorectal cancer care; extends pooled observational evidence on independent mortality risk.
Xia et al. (2024) conducted a meta-analysis in Colorectal cancer (n=26,907). Depression and anxiety vs. No depression or anxiety was evaluated on All-cause mortality associated with depression (multivariate analysis) (HR 1.62, 95% CI 1.27-2.06, p=<0.00001). Depression was associated with a 62% increased risk of all-cause mortality in patients with colorectal cancer (HR 1.62), whereas anxiety was not significantly associated in multivariate analysis.
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